Lamotrigine Induced Pancytopenia and Sepsis: Case Report and Literature Review
Lamotrigine Induced Pancytopenia and Sepsis: Case Report and Literature Review
Research & Reviews: Journal of Hospital and Clinical Pharmacy (RROIJ Publishing) is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of not only Hospital and Clinical pharmacy but also in aspects like Drugs & Drug information studies, General anesthesia, Automatized anesthesia, Pediatric Anesthesia, Obstetric Anesthesia, Neuroanesthesia, All kind of surgeries General medicine & Critical care medicine, Preoperative Evaluation & Postoperative effects, Pain management, Drug information studies, Clinical reviews, Pharmacy practices, Patient care & Counseling, Ischemia reperfusion, Clinical trials, Patient management, Patient care, Nursing, Disease and hospitalization, Trauma care, and Incentive care etc.
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The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Review article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.
Title: “Lamotrigine Induced Pancytopenia and Sepsis: Case Report and Literature Review”
Abstract: Drug induced pancytopenia is a serious adverse reaction that can be fatal due to the lack of early detection and treatment. A number of case-reports suggest that lamotrigine (LTG), a second-generation anticonvulsant, is associated with blood dyscrasias. [1-25] Despite multiple serious case reports, one reported fatality, and manufacturer recognition of LTG- induced haematological abnormalities upon drug initiation, current guidelines for monitoring still do not exist. Here, we report a life-threatening case of LTG- induced pancytopenia leading to sepsis and provide a literature review of case reports. A 25- year- old hypotensive and febrile female reported to the emergency department following a 3 week course of LTG. On admission, the patient was found to be septic with pancytopenia. The patient was transferred to the ICU and was successfully treated with fluid resuscitation, vasopressor therapy, broad-spectrum antibiotics, and granulocyte colony stimulating factor. The patient was discharged home on hospital day 6 with an alternative anticonvulsant regimen of topiramate and levetiracetam. This provides evidence of a temporal relationship with the initiation and discontinuation of LTG therapy that suggests LTG was a probable cause of pancytopenia that led to sepsis in this patient. Clinicians need to be aware of this serious adverse event and should be informed on the importance of performing routine haematological monitoring during the induction of LTG therapy.
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Research & Reviews: Journal of Hospital and Clinical Pharmacy
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