Inhibition of Protease Activity of Periodontopathogens by Purified Lactoferrin and Lactoferrin Supplement

Journal of oral hygiene and Health has announced almost 20 percent discount on article processing charge to commemorate its Anniversary. On behalf of the Journal of oral hygiene and Health the editor of Journal of oral hygiene and Health is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations.

Oral hygiene is the practice of keeping one's mouth clean and free of disease and other problems (e.g. bad breath) by regular brushing of the teeth (dental hygiene) and cleaning between the teeth. It is important that oral hygiene be carried out on a regular basis to enable prevention of dental disease and bad breath. The most common types of dental disease are tooth decay (cavities, dental caries) and gum diseases, including gingivitis, and periodontitis.

INTRODUCTION

Periodontitis is caused by periodontopathic bacteria such as Porphyromonas gingivalis and Tannerella forsythia, which are components of so-called red-complex bacteria. P. gingivalis has several biologic activities, and one of the most important properties is protease activity named gingipain We have previously isolated gingipain and reported its suppressive activity on human neutrophils and confirmed its virulence in a mouse mixed infection model with P. gingivalis and T. forsythia. Gingipain was also found to be related with the growth promotion of P. gingivalis by T. forsythia.

 Periodontitis is caused by periodontopathic bacteria such as Porphyromonas gingivalis and Tannerella forsythia. P. gingivalis has several biologic activities such as protease secretion. Inhibition of protease activities of periodontopathogens is one of the most effective strategies to prevent the progression of periodontitis. Lactoferrin, an iron-binding glycoprotein, is considered to be a useful tool for this purpose, and lactoferrin supplements may be effective for health promotion. In this study, the effect of purified lactoferrin on P. gingivalis and T. forsythia protease was examined. The effect of lactoferrin supplement on protease activity was also tested. The purified lactoferrin inhibited the protease activity of both periodontopathogens. Lactoferrin supplement also exhibited the inhibitory effect. From these results, lactoferrin and lactoferrin supplement are considered to contribute to the prevention of periodontitis by inhibiting the protease activity of periodontopathogens.

The Journal is successfully running in the 8^th Volume which covers a wide variety of Researchers of Oral Hygiene and Dental Health discipline are encouraged to publish innovative ideas in the international platform and peer reviewed journal of oral care and hygiene with good Impact factor. Oral hygiene, oral cancer, and oral surgery are some of the most evolving sectors of dental sciences, which still need more findings and communication. Hoping to contribute your work in our journal of Oral hygiene and health. We accept Original articles, rewiew articles, short commentaries etc.,

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Suzanne,
Managing Editor,
Journal of Oral Hygiene and Health
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