Prevention, Management and Prediction of Prognosis in Cervical Cancer


The Journal of Oncology Translational Research aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal is published by Insight Medical Publishing who hosts open access peer-reviewed journals as well as organizes conferences that hosts the work of researchers in a manner that exemplifies the highest standards in research integrity.

Although the overall incidence of cervical cancer has not changed significantly, it has become increasingly common in younger women in many countries, new challenge for management. Nearly 85% of cervical cancer deaths occur in developing countries and India reports about 122,000 new cases of cervical cancer annually and accounted for 25% of all cervical cancer deaths (67,500 deaths) Ferlay reported that cervical cancer was the third most common cancer in women, and the seventh overall, with an estimated 529,000 new cases in 2008. A total of 1,658,3770 new cancer cases and 589,430 cancer deaths were projected to occur in the United States in 2015. In a rural institute analysis of cancer cases in women revealed that cervical cancer constituted 29% of all cancers in women, similar to other reports. Unfortunately very few women complied to therapy. Follow up after completion of therapy has also been very low. All these challenges need more research, which too is a challenge in places where cervical cancer is most common.

Usually, management of cervical cancer is as per age, parity, stage of cancer, associated disorders. It may be conservative or aggressive multimodality therapy. However after planned therapy outcome is not always as per expectations. Answers need research. Nearly 20% of women with cervical cancer die within the first year of diagnosis. Research continues about factors which affect outcome and recurrence after surgery, radiotherapy, chemoradiotherapy, and differences in efficacy of surgery, chemotherapy, radiotherapy. Despite significant developments in management, results seem to be far from optimal. Over years there has been no demonstrable reduction in the incidence of cervical cancer and deaths due to cervical cancer. More than 50% of women diagnosed with cervical cancer are younger than 50 years, so the quality of life is becoming a challenge. Sometimes extensive surgeries like complete or anterior or posterior exenteration might give satisfaction to treating surgeon but what matters is survival with quality. It is not possible to predict the prognosis and know the best therapy for recurrent disease. In developing countries lack of awareness about prevention, geographical, economic inaccessibility, poor quality services, lack of support from families are barriers to early diagnosis and also safe therapy. A lot of more research seems to be necessary for the best therapy.

In spite of being almost preventable cancer mortality due to cervical cancer continues to be high. At present, it is mostly not possible to predict prognosis. Appropriate management needs more research and a lot needs to be researched about prognosis too.

Jessica Rose
Journal of Oncology Translational Research
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